Associate Vice President, Generative Design & Optimization, Biotherapeutics Greater San Diego, CA Area

The Company is seeking an Associate Vice President for Generative Design and Optimization in Biotherapeutics. This pivotal role is focused on advancing the frontiers of de novo protein design to create novel therapeutic candidates with enhanced activity, safety, and target coverage. The successful candidate will be responsible for defining and executing the scientific strategy that integrates AI/ML, protein engineering, automation, and structural biology to develop a generative design platform. This platform will be capable of generating, ranking, and optimizing therapeutic molecules, with a strong emphasis on experimental validation and continuous learning. The AVP will lead a high-performing organization, establish long-term capabilities in de novo biologics design, and ensure that the design platform evolves to meet the increasing complexity of biologics discovery challenges. Applicants for this role at the company should have a Ph.D. in a relevant STEM field, with at least 5 years of post-Ph.D. research experience, or an M.S. with over 10 years of experience. A strong background in leading scientific or engineering teams, as well as a proven track record in computational or generative molecular design, is essential. The role requires proficiency in Python and modern deep learning frameworks, with a preference for expertise in areas such as conditional generation, active learning, and multi-objective optimization. The ideal candidate will have a deep understanding of structural biology and experience in therapeutic protein design, particularly in the context of antibodies, peptides, or other biologics. Excellent communication skills and the ability to collaborate across disciplines are also key requirements for this leadership position.

Hiring Company

Eli Lilly and Company