Executive Director, Head of Peptide Macrocycles Medicinal Chemistry Greater Los Angeles, CA Area

The Company is seeking an Executive Director - Head of Peptide Macrocycles Medicinal Chemistry to lead the medicinal chemistry and lead optimization efforts across all macrocycle programs. The successful candidate will be responsible for overseeing the group that works closely with the macrocycle discovery team to advance hit compounds and early leads to candidate designation. This role requires a deep understanding of molecular engineering, structure-guided medicinal chemistry optimization, and a proven track record in advancing programs to the clinic. The ideal candidate will have a Ph.D. in a relevant field, extensive experience in synthetic chemistry, and a mastery of the latest developments in oral macrocycles and macrocyclic peptides. Key responsibilities for the Executive Director include formulating and executing strategy for the technical development of macrocycle compounds, leading the team in molecule engineering efforts, and inspiring a collaborative and high-quality scientific environment. The role demands a leader who can manage scientific group milestones, mentor junior scientists, and is adept at partnering with cross-functional groups in the drug discovery process. The candidate should have a strong background in medicinal chemistry, experience with library-based screening technologies, and a proven ability to make decisions in the face of ambiguity. A successful track record in drug development, including the progression of molecules from conceptual stage to clinical testing, is essential. The ideal candidate will also have a deep understanding of AI and machine learning techniques in the development of oral macrocyclic peptide medicines and be an excellent team player with a strategic mindset.

Hiring Company

Eli Lilly and Company