Executive Director, Chemical Engineering Lead Greater Philadelphia, PA Area

The Company is seeking an Executive Director, Chemical Engineering Lead to set engineering strategy and oversee execution for drug substance and drug product processes. The role ensures processes are scalable, safe, manufacturable, and transferable to external manufacturing partners. Responsibilities include establishing standards for scale-up readiness and equipment suitability, supporting process parameters and operating ranges, and leading engineering contributions to technology transfer, safety reviews, and risk assessments. The successful candidate will also address scale-up constraints, identify opportunities to improve yield and throughput, and ensure documentation supports validation and audit readiness. Candidates must have a bachelor’s degree or higher in Chemical Engineering, with an advanced degree preferred, and at least 18 years of process or chemical engineering experience supporting GMP manufacturing and technology transfer. Demonstrated leadership in scale-up, process safety, and collaboration with external manufacturers is required, along with strong cross-functional influence and structured problem-solving skills. Preferred qualifications include experience with SDD process scale-up, solvent and safety considerations, and validation or PPQ readiness. Key strengths include manufacturability, continuous improvement, rigorous documentation, and effective stakeholder communication.

Hiring Company

Madrigal Pharmaceuticals